Statins – More than Drug Against Cholesterol!
Statins are drugs available on prescription, and they are used to lower cholesterol. They prevent your body produces more cholesterol and can help your body to reabsorb cholesterol that is already present in the walls of arteries.
Not all people who have high cholesterol take statins. The drug is recommended for people who are at high risk of heart disease.
Drug Against Cholesterol
Individuals with a family history of heart disease and high cholesterol will probably be prescribed statins. Other risk factors such as obesity or diabetes may require use statins.
Besides statin therapy is recommended for people with cardiovascular disease, diabetes, or significantly elevated levels of cholesterol, it is also recommended for people who do not have these problems but have an increased risk of heart attack or stroke over the next ten years, according to the calculated risk scale. This scale includes age, gender, race, and if the calculated risk for a period of 10 years is greater than 7.5%.
Since age as a risk – factor is sufficient for the elderly to cross the threshold of 7.5% even when their cholesterol level is normal, it is estimated that people aged between 66 and 75 years should take statins, to reduce the risk of heart attack or stroke.That applies to 100% of men in that age.
The idea that cholesterol plays a key role in heart disease is so tightly woven into modern medical thinking that is no longer considered open to question. That is the message all too clear from the recent news that the drug “Vytorin” fared no better in clinical trials than statin therapy, which was supposed to supplant. “Vittorio” is a combination of drugs to lower cholesterol, ie one “Zetia” and other statin “Zocor”.
Since both drugs lower LDL cholesterol by different mechanisms, the makers of “Vittorio” ( “Merck” and “Plow”) assumed that their double-barreled therapy would lower it more than any other medicines – such as receipts, and thus a better job of slowing the accumulation of fatty plaques in the arteries – which it did not.
Heart disease specialists who were asked to comment on this development insisted that the result implied nothing about their assumption that LDL cholesterol is dangerous, but only if it is always medically effective to decrease. But this interpretation is based on a longstanding conceptual error embedded in the very language we use to discuss heart disease.
The make confuses of the cholesterol carried in the bloodstream in particles called lipoproteins that that cholesterol around.There is little doubt that some of these lipoproteins pose dangers, but whether cholesterol itself is a critical factor is the question that the “Vytorin” imposed. It is a question that should be recognized and addressed if we want further progress in preventing heart disease.
To understand the difference between cholesterol and lipoproteins, it is desirable to know the history of research on cholesterol. In the 1950s, two hypotheses competed for attention among heart disease researchers.
For decades it was known that cholesterol is a component of atherosclerotic plaques, and people who have a genetic disorder that causes extremely high cholesterol levels typically have clogged arteries and heart attacks. However, as new technology enabled them to look more closely at lipoproteins, researchers have begun to suspect that these carrier molecules might play a greater role in cardiovascular disease than cholesterol in them.
However, cholesterol hypothesis dominated, because analyzing lipoproteins was still expensive and difficult, while cholesterol tests were easily ordered up by any doctor.
In the late 1960s, biochemists created a simple technique for specifically measuring cholesterol inside the different types of lipoproteins – high density, low density and very low density. National Institutes of Health funded several studies to determine whether these “fractions of cholesterol” can predict the risk of cardiovascular disease.
In 1977, researchers published their results: total cholesterol proved surprisingly useless as a predictor. Researchers Study Framingham heart disease found that in men and women from 50 and older, “total cholesterol per se is not a risk factor for coronary heart disease in general.”
The cholesterol in low-density lipoprotein is considered “marginal risk factor” for heart disease. Cholesterol high-density lipoprotein was probably the best determinant of risk, but with the opposite correlation: the higher the amount, the lower the risk of heart disease.
These findings led directly to the notion that low-density lipoprotein wear etc. bad cholesterol and high-density lipoproteins carry etc. good cholesterol. And then the precise terminology was rejected in favor of the common shorthand. HDL and LDL lipoproteins become good cholesterol and bad cholesterol, and lipoprotein transport vehicle was now conflated with its cholesterol cargo.
Lost in Translation was evidence that the cause of heart disease might be abnormalities in the lipoproteins themselves.
Another important piece of evidence for the cholesterol hypothesis is that statin drugs, such as “Zocor” and “Lipitor” lower LDL-cholesterol and also prevents heart attacks. The greater potency of statins, the cholesterol lowering and the fewer the heart attacks. It is understood as implying cause and effect: Statins lower LDL cholesterol and prevent heart disease, so reducing LDL cholesterol prevents heart disease.
This belief so convincingly is holding what brings to the Administration Food and Drug Administration now approves drugs to prevent heart disease, as it did with “Zetia” solely on the evidence that they lower LDL-cholesterol. But the logic is specious because most drugs have multiple actions. It’s like insisting that “aspirin” prevents heart disease by getting rid of a headache.
Negative effect from statins includes diarrhea, rash, high blood sugar, memory loss, constipation, drowsiness.
But the worse is that these are not so serious effect compared withmysositis and rhabdomyolysis. These are conditions that lead to inflammation of the muscles and can lead to serious muscle damage and kidney damage to. Your kidneys can result with a big failure even death.
Also several studies shows that these medicaments can prevent cancer too. They can increase the risk of prostate and breast cancer. The statins are connected with immune system, they can affect it, increase the body’s production of T cells and in this way they leave susceptible place to developing cancer.